An alternative of midazolam is dexmedetomidine and it can have less unintended side effects than midazolam. Why is midazolam so popular and why is it the medication that is used over other ones? What made it so popular if it can have adverse effects?
Wang, L., Yang, H., & Le, X. (2023). Comparison of dexmedetomidine with midazolam for third molar surgery: A meta-analysis of randomized controlled trials. Medicine, 102(25), e33155. https://doi.org/10.1097/MD.0000000000033155
This is very interesting to read. I can see why midazolam is an attractive sedative for EMS systems as the complication rate is low. According to a paper (Klein, 2018), IM Midazolam is also an appreciated sedative preferred over other sedatives in the emergency department (ED) as it can sedate patients faster.
Since Midazolam is so effective in surgeries and don't have a lot of complications for EMS, I think we need to weigh the risks of taking Midazolam and the good that it can do, and consider when to best use it. According to Mayo Clinic, there are things that could be considered in the EMS systems regarding the use of Midazolam to reduce the adverse cases that happened including if the patient has allergies to the drug, research on the relationship between midazolam usage and age, and midazolam interactions with other drugs that the patient might be taking at the time of injection.
Klein, L. R., Driver, B. E., Miner, J. R., Martel, M. L., Hessel, M., Collins, J. D., Horton, G. B., Fagerstrom, E., Satpathy, R., & Cole, J. B. (2018). Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation in the Emergency Department. Annals of emergency medicine, 72(4), 374–385. https://doi.org/10.1016/j.annemergmed.2018.04.027
Midazolam (Injection Route). Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/midazolam-injection-route/side-effects/drg-20064813?p=1
An alternative of midazolam is dexmedetomidine and it can have less unintended side effects than midazolam. Why is midazolam so popular and why is it the medication that is used over other ones? What made it so popular if it can have adverse effects?
ReplyDeleteWang, L., Yang, H., & Le, X. (2023). Comparison of dexmedetomidine with midazolam for third molar surgery: A meta-analysis of randomized controlled trials. Medicine, 102(25), e33155. https://doi.org/10.1097/MD.0000000000033155
Hey Kelby!
ReplyDeleteThis is very interesting to read. I can see why midazolam is an attractive sedative for EMS systems as the complication rate is low. According to a paper (Klein, 2018), IM Midazolam is also an appreciated sedative preferred over other sedatives in the emergency department (ED) as it can sedate patients faster.
Since Midazolam is so effective in surgeries and don't have a lot of complications for EMS, I think we need to weigh the risks of taking Midazolam and the good that it can do, and consider when to best use it. According to Mayo Clinic, there are things that could be considered in the EMS systems regarding the use of Midazolam to reduce the adverse cases that happened including if the patient has allergies to the drug, research on the relationship between midazolam usage and age, and midazolam interactions with other drugs that the patient might be taking at the time of injection.
Klein, L. R., Driver, B. E., Miner, J. R., Martel, M. L., Hessel, M., Collins, J. D., Horton, G. B., Fagerstrom, E., Satpathy, R., & Cole, J. B. (2018). Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation in the Emergency Department. Annals of emergency medicine, 72(4), 374–385. https://doi.org/10.1016/j.annemergmed.2018.04.027
Midazolam (Injection Route). Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/midazolam-injection-route/side-effects/drg-20064813?p=1